Hi It looks as though Ionis are starting to enrol a second wave for their very exciting HTTRx trial!by Kathy61 - Huntington's Disease Support Center
Hi This is an update from Prof Tabrizi at the Annual HD Theraputics Conference on the Ionis Htt trial. Looking exciting! You might also find this article interesting ....... Kxby Kathy61 - Huntington's Disease Support Center
Professor Tabrizi at UCL is very involved with this trial. You can find some information here In the interview she gives she stresses that the initial trial will be solely for safety but some articles I have read this week in the UK state that they are now also looking at the effect of the drug on trial participants. That is why is is now called a 2a trial as well. I still think thatby Kathy61 - Huntington's Disease Support Center
The long awaited European Isis-htt trial looks to have begun. I was interested to see that it is now a stage 1/2a trial. Initially we were told that it would be a stage 1 trial just for safety but they seem to be also looking at it's initial effects on symptoms. This is the first drug of it's kind - the first to attack HD at the roots. Any thoughts /comments Marsha? Kathy xby Kathy61 - Huntington's Disease Support Center
Marsha, You say a clinical trial could start in 18 months. Do you mean a Phase 1? Or have they already completed the early trials and you mean phase 3? Thank you Katy xby Kathy61 - Huntington's Disease Support Center
Marsha - Here in the UK we have a 2mg MR melatonin tablet under the brand Circadin. Here's a link to it's release on the NPC website - Kathy xby Kathy61 - Huntington's Disease Support Center
Thanks for the replies. So does anyone know of any clinical trials that are due to start in the next 12 - 18 months that could offer an actual "cure" or stall the disease? I know there are late stage trials for creatine, COQ10 etc, and, of course Huntexil - but are we on the verge of seeing at least a few trial participants "cured"? Kathy xby Kathy61 - Huntington's Disease Support Center
Hi - This may be one for Marsha or someone more clinically minded than myself! I have been reading this article about Stem Cell Research at UC Davis - One sentence that jumped out at me was - " The awards are specifically designed to support collaborative research that will bring potential therapies to the Food and Drug Administration for approval within four years" Areby Kathy61 - Huntington's Disease Support Center
Marsha - Do you think the treatment will only be available to non symptomatic patients - i.e. it will stop them ever becoming symptomatic - or will they also use it on symptomatic patients to stop the disease progressing? Thanks Kathy xby Kathy61 - Huntington's Disease Support Center
Hi Everyone, This was in the UK press today. Kathy xby Kathy61 - Huntington's Disease Support Center
Thanks Marsha, Kathyby Kathy61 - Huntington's Disease Support Center
Hi There has been a lot in the medical press over the last few days about the advantages that antioxidants could have for HD patients. As Cystamine is an antioxidant can you update me on whereabouts in the trial program this drug is and whether you feel it should become available for HD sufferers sooner rather than later given this new evidence on antioxidants? Thanks Kathyby Kathy61 - Huntington's Disease Support Center
Hi everyone, Thought you might be interested in this... Kathyby Kathy61 - Huntington's Disease Support Center
Hi As I'm still new to the site I apologise if this has already been discussed, but I came across this article today that looked quite interesting. Kathyby Kathy61 - Huntington's Disease Support Center
Hi everyone, I've been reading all the info I can about creatine and how it can possibly slow doen the early progression of HD and just wondered how many of you take it and in what dose? Also, how long have you been taking it for and, more importantly, do you feel it has had any significant effect? Is it better to take it in combination with other supplements? Thanks, Kathyby Kathy61 - Huntington's Disease Support Center
Sounds interesting. Glad we have Marsha here to sort through these updates! Does anyone know what the next stage of drug development will be and when it will be likely to start? Kathyby Kathy61 - Huntington's Disease Support Center
Hi Joe, Sorry to hear your news. My husband has just begun with symptoms and I feel overwhelmed by the prospect of what is to come. Everyone on here is lovely and I know you'll find the strength to carry on through their help and advice. Kathyby Kathy61 - Huntington's Disease Support Center
Hi everyone, - and firstly many thanks for your messages of support after my first post yesterday. As I said in that post, my husband was showing signs of movement disorder but can anyone tell me whether it is possible for a person to control those movements - especially in the early phase. We were in bed last night and the cat decided to join us, wrapping herself around his legs. Consciousby Kathy61 - Huntington's Disease Support Center
Hi Rowan, It's a great comfort to know that there are people like you out there who know what I am going through. Please keep in touch if you would like to. Kathyby Kathy61 - Huntington's Disease Support Center
Thank you both for your kind words and welcome. JFB - I have sent you a private mesage. I hope you don't mind. Kathyby Kathy61 - Huntington's Disease Support Center
Hi I'm new to this site and have found it very helpful over the past few days since my husband began showing signs of HD. To say that I'm devastated is an understatement. He'll be 50 in a couple of months and has begun to be fidgety and restless - he can't sit still without scratching, moving etc. There are no other symptoms as yet but I am convinced that this is the beginning. I haven't saidby Kathy61 - Huntington's Disease Support Center