In the abstract of the research paper "Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons" it states:
"At the mechanistic level, trehalose treatment led to a drastic upregulation in the expression of key autophagy-related genes at the mRNA level including Lc3, Becn1, Sqstm1 and Atg5. Consistent with these changes, trehalose administration enhanced the nuclear translocation of FOXO1, an important transcription factor involved in the activation of autophagy in neurons."
Here's a link to the research paper:
[
www.landesbioscience.com]
