I've been asked to participate in a Phase 1b trial for Siena Biotech's SIRT1 Inhibitor, named Selisistat. It's a short, intensive trial at Wake Forest University, primarily evaluating safety. My initial screening visit is scheduled for April 30th, with the dosing period starting about 28 days after that.

Marsha and Remig can explain again why this is important, but it's GOOD NEWS! This has the potential to be a disease modifier, not just a symptom treatment. I'm pleased to be a part of it.

Will

great news Will. Congrats!

Thanks Will for doing your part in reaching a cure

Thank you, Will, for sharing this wonderful news and taking such an active role in the search for a cure!

Hi Will-

Thank you very much for participating in this trial! What you are doing is important. I am sure your fine example will inspire others to participate in this, and other trials and studies.

Cheers,

Robi

Robi Blumenstein
CHDI Management/CHDI Foundation
robi.blumenstein@chdifoundation.org
www.chdifoundation.org

Thanks all for the kind words, all. This is a small study at only 6 sites with 4 to 6 people per site, according to my information. I don't know the other sites besides Wake Forest. You don't have to be symptomatic to participate - just be healthy and have the gene. You also have to be fairly close to the site since there are a number of visits (and a lot of hours) during the dosing period.

Will

Will, I hope your efforts reap rewards for us all in the long term.
Thank goodness for research and willing subjects ....

I volunteered for the UK trial but it seems the nearest place is about 3 hours drive and lots of check ups so I just
cant't factor this in with looking after my kids/work/mother etc etc...

Keep us informed please of what the trial entails and what the results will prove etc etc

Lorraine x

Thanks again, Will, for your participation in research! I hope you will write another article about your experiences. There was so much interest in the last one you wrote and I think it helps people who are considering clinical trials to learn about what it's like to participate.

what are the sites Marsha?? We are in NY and are always interested.

Here's a complete list and a description of the trial. [clinicaltrials.gov]
There is a site in NY at the University of Rochester.

Will

Good Morning Will,

I have been waiting for a chance to meet you online. My husband is also participating in the trial we are doing it in San Diego. You have been a real inspirtation to us an we always enjoy your posts about suppliments and execise. Keep up the good work and good luck in the trial.

Nice to meet you, Debi. I'm also married to a Debbie. Some years ago I went to three separate 2 week military schools at the Navy Amphib Base on Coronado Island. We fell in love with the Island and the rest of San Diego. I still have vivid memories of running past the Hotel Del Coronado on the boardwalk next to the Pacific.

Will

Thanks a lot Will. It is a valant effort to participate.
Best Wishes
Mike

Will, one daughter is Debbie (CAG 42 Age 49).
As an enlisted Air Force airborne Russian linguist, I went through Physiological and Psychological training in Nevada with the SEALs in 1962 (the year of their formation).. I did get to San Diego several times; tis beautiful. bob.