I was checking out Google News on Huntington's disease and I came across the Medivation Dimebon article.

There was also a very interesting article on Myelin and its role in Huntington's.

I would be interested to know if anybody had any thoughts on Dimebon as a treatment and on myelin and potential early treatments. Do any of the existing treatments such as Creatine address the effects of myelin.

"Dimebon has two promising two mechanisms. It is an acetylcholinesterase inhibitor like other drugs which have been shown to be effective in Alzheimer?s disease and it also blocks glutamate receptors, much like memantine. Those mechanisms may address cognitive and behavioral problems in Huntington?s Disease.

The study is underway. There are two phases, the early dose finding phase and then a larger placebo controlled and double blinded to look for signs of efficacy. Phase I and II are bundled together. If Phase I and II look promising, a larger phase III study will be needed. "

Steve I