From a reading of the abstract, I think it means this: Proteins in the cell are constantly being renewed and protein synthesis never stops. Some proteins must be synthesized at constant rates while others can vary in their rates. To my understanding, proteins regulated by mTOR vary their rates according to nutrient availability. The paper seems to suggest that the HD mutation causes the huntingtby remig - Huntington's Disease Support Center
Head trauma is thought by many to initiate motor neuron diseases such as ALS, a disease with many similarities to HD in terms of progression. One hypothesis is that some traumas may temporarily disrupt the blood-brain barrier that isolates the central nervous system from the general circulation and expose nerve tissues directly to mis-folded proteins therein. These mis-folded proteins may then seby remig - Huntington's Disease Support Center
Here is a pdf charting expected onset for the full range of CAG counts.by remig - Huntington's Disease Support Center
Marsha: thanks for the link. I missed that discussion the first time around. I suggested above that curcumin capsules might just be unrefined turmeric powder. That is apparently not the case. Curcumin capsules contain 95% curcuminoids whereas turmeric powder contains only 5%. A TB of turmeric powder (15 grams) would therefore contain 750 mg of curcumin, about the same as in a typical curcuby remig - Huntington's Disease Support Center
With regards the original topic that fish oil and turmeric were causing digestive upset, both are available in enteric coated capsules. An enteric coating prevents the capsule from dissolving until it reaches the intestines. Though I have no personal experience, this might minimize your problems. Has anyone on the forum tried enteric coated capsules?by remig - Huntington's Disease Support Center
Marsha: do you have a link to the conclusions of Jeff Carroll and Lavonne Goodman against curcumin?by remig - Huntington's Disease Support Center
Barb: are you sure we are talking about the link you posted? The article says nothing about recommending anything.by remig - Huntington's Disease Support Center
Curcumin is the active ingredient in turmeric and is widely available in capsule form. In fact those capsules appear to just contain turmeric powder with no further refinement. Curcumin is a known autophagy inducer. Barb: the article you cite has no mention of either curcumin or turmeric. Where else has it been mentioned that curcumin is contraindicated for HD?by remig - Huntington's Disease Support Center
Here is an even cheaper site. 20 LB @ $4.75 LB + $14.00 shipping = $109.00 total I have never actually ordered from this site but it is the cheapest I've seen...by remig - Huntington's Disease Support Center
SIRT1 activation is a known promoter of autophagy and this is the likely mechanism that delays HD progression.by remig - Huntington's Disease Support Center
papple_juice: locus is just the technical term for the location of the gene on the chromosome. Your cells each have two copies of chromosome 4, one from your father and the other from your mother. Germ cells (eggs and sperm) have only one copy of chromosome 4 (representing about 6% of your total genes). That one copy has some stretches from your mother's chromosome and some from your father'sby remig - Huntington's Disease Support Center
The gene for the protein huntingtin is on chromosome 4. Human eye and hair color genes are on other chromosomes and therefore should sort totally independent of hd. Sharing such traits with a phd parent should therefore imply no greater likelihood of sharing hd. There is one gene on chromosome 4 associated with red hair but it is too far from the huntingtin locus to have appreciable inheritaby remig - Huntington's Disease Support Center
MJD and HD are practically the same disease differing only in the particular protein on which the CAG expansion occurs. The study cited mirrors similar studies on HD where autophageosome maturation (i.e. fusion with lysosomes) is inhibited because the rate-limiting component in the maturation process, beclin-1, gets tied up in the aggregates of the mis-folded proteins characteristic of both diseby remig - Huntington's Disease Support Center
On my part, I protein fast three times a week since an amino acid deficiency should induce autophagy as readily as a calorie deficiency and is much less stressful.by remig - Huntington's Disease Support Center
Actually autophagy has been observed in yeast where a lysosome encloses and digests a portion of the nucleus. Though this has not yet been observed in higher life forms, it remains a possibility, especially in view of the fundamental and conserved role of autophagy in the life of nucleated cells.by remig - Huntington's Disease Support Center
JudyF: The question of the liklihood of older siblings having HD when it manifests in a younger sibling can be answered though there are factors that cloud the accuracy of the result. If you bear with me, I will try to give you an answer. The Stanford HOPES site has an article at that gives the average age of onset for a given CAG count and the range within which 85% of Phds with that count lby remig - Huntington's Disease Support Center
It may simply be that HD testing does not fit their general testing protocol. My guess is that they test with fluorescent RNA probes binding to your DNA sample where the RNA sequence matches the gene they are looking for. If it binds, you have the gene, otherwise not. This approach does not work for HD since it is the extended length of the CAG repeat on an otherwise normal gene that producesby remig - Huntington's Disease Support Center
Though the claim is that NeruoAid promotes BDNF, a promising HD therapeutic target, there is much in the way of any clinical testing. From wikipedia: "Danqi Jiaonang is a traditional Chinese medicine preparation containing a mixture of 14 herbal and plant extracts. It was initially developed by the First Teaching Hospital of Tianjin in China. Danqi Jiaonang is approved and marketed in Sby remig - Huntington's Disease Support Center
maahearna: First off, there is some ribose in food, specifically from the digestion of nucleic acids, RNA and DNA. The site you reference that praises ribose links to itself to sell ribose at over twice the going rate, not exactly an unbiased review. I once included ribose in the cocktail I provided my phd. The rationale was that glutathione, the principle intra-cellular anti-oxidant, deby remig - Huntington's Disease Support Center
In the cells, lithium creates a shortage of the lipid inositol required for membrane synthesis. The cell then initiates autophagy to recover inositol from existing surplus membranes. This autophagy to meet the inositol need may then clear out some of the protein aggregates associated with HD as well and this might explain the its reported benefits. If so, the lithium would then have to be withby remig - Huntington's Disease Support Center
Glutathione has been discussed previously on this forum . It is manufactured by the body and is its principal intra-cellular anti-oxidant. Interestlingly acetaminophen (paracetamol) is toxic when its metabolism depletes it in the liver. I assume you are referencing practitioners who inject it directly into the blood stream. It is hard to understand how such a practice would be beneficial unlby remig - Huntington's Disease Support Center
That's over $6 per gram. You can buy CoQ10 in powder form for a little over $1 per gram . Sprinkled over food, the powder would likely be better absorbed than the capsule form.by remig - Huntington's Disease Support Center
Luz, I applaud what you are doing. Will you be translating forum messages as well?by remig - Huntington's Disease Support Center
I think the translation sites do an adequate job. I use them to follow the French forum at and have no real problems with meaning even if the idiom is strained. Most problems for me trace to mis-spellings, usually missing accent marks.by remig - Huntington's Disease Support Center
There are on-line translation sites that will translate entire web pages to any popular language such as Google's site at . For example, this link translates this very page to Spanish. And this link translates it to French. And this link to Japanese if you have loaded the Japanese character set. Note that as you navigate from a translated page, the next page is translated as well.by remig - Huntington's Disease Support Center
Allowing for journalism license, I do not think the reporting on this study has been at all irresponsible or misleading, the Science Daily report in particular . Though many steps removed from a cure, the research discussed here does to me seem to represent a significant break-through, a clear exposition of why the corpus striatum is the first tissue type to fail in HD. The tool set and methodby remig - Huntington's Disease Support Center
Yes, it is a work in progress. My phd has been on the regimen for two years but is showing decline in walking. His doctors have him on olanzapine (Zyprexa). A recent open-access technical review of autophagy in neurodegenerative diseases is now available at .by remig - Huntington's Disease Support Center
Frankly 'best' hardly matters. In fact cheapest may even be better since it would most likely then come from wild mackerel rather than from farmed salmon. Just take as many as needed to get the desired dosage. Pre-industrial diets were about even in ratio of omega-6 fatty acids to omega-3s. The balance has now shifted heavily to the omega-6 side and supplementation should be used to correctby remig - Huntington's Disease Support Center
Yes, both resveratrol and curcumin have been shown to cross the blood-brain barrier. The other supplements I provide my phd have been listed in an earlier post . Since that time, I have modified the schedule for resveratrol and curcumin as described here, added cinnamon and ashwaganda to the days when resveratrol and curcumin are withheld and have substituted beta-alanine for carnosine.by remig - Huntington's Disease Support Center