CHDI, Inc. Update
LaVonne Veatch Goodman, M.D., Sun, 01/22/2006
Lighthouse contributing editor LaVonne Goodman reports on a meeting at CHDI.
Basic Research
Mutant huntingtin alters MAPK signalling pathways
Marsha Miller Ph.D., Fri, 01/13/2006
MAPK/ERK and SAPK/JNK pathways are affected by mutant huntingtin. Researchers were able to manipulate the pathways to prevent problems caused by mutant huntingtin in the cellular model they used.
A clue regarding huntingtin fragments
Cong SY, Pepers BA, Roos RA, van Ommen GJ, Dorsman JC., Tue, 01/03/2006
Surprising findings about huntingtin aggregation...
Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity
Shin JY, Fang ZH, Yu ZX, Wang CE, Li SH, Li XJ, Thu, 12/29/2005
Mutant huntingtin accumulates in glial nuclei in HD brains and decreases the expression of glutamate transporters.
Bistability of protein aggregation: Mathematics to the rescue?
Rieger TR, Morimoto RI, Hatzimanikatis V., Sun, 12/18/2005
Researchers are using mathematical modeling to gain new insights about Huntington's Disease.
A growth factor, FGF-2 generates new neurons in the R6/2 mice
Jim, Lafevre-Bernt, Sun, Chen, Gafni, Crippen, Logvinova, Ross, Greenberg, and Ellerby, Sun, 12/11/2005
FGF-2 promotes neurogenesis and increases survival time in the HD mouse.
BDNF Generates Neurons in the Striatum of Primates
A. Bedard, C. Gravel, and A. Parent, Tue, 12/06/2005
BDNF causes neurogenesis in the striatum in primates.
Huntington Study Group 2005 Annual Meeting Report
Jim Tretheway and Marsha L. Miller, Ph.D., Sat, 12/03/2005
Two members of the HDLighthouse editorial staff were guests at the 2005 Huntington Study Group meeting.
Low Brain Cholesterol: Another Bullet.
Elena Cattaneo and colleagues, Sun, 10/30/2005
Dr. Elena Cattaneo and colleagues have discovered another HD pathology.
Three Papers on Heat Shock Proteins - Do You Need A Chaperone?
Malcolm Casale, Ph.D., Mon, 10/17/2005
A better understanding of heat shock proteins may lead to HD treatments.
