Autophagy increases but is impaired, leading to an increase of the HD protein in the cytosol.
This is a landmark study because it brings together and adds to previous research and points to a potentially significant treatment.
Coalition researcher Dr. Michael R. Hayden teamed up with Dr. Stuart Lipton,
Clear differences were found among the control group, premanifest gene carriers, and those in early stages.
This article describes other possible diagnoses when there are clinical signs of HD but a negative gene test.
