Factors Associated with HD CAG repeat instability in Huntington's disease
Marsha L. Miller, Ph.D., Mon, 08/13/2007
A new study based on Venezuela data examines factors that might be associated with CAG expansion .
CAG
CAG Counts Unrelated to Psychiatric Symptoms in HD.
Marsha L. Miller, Ph.D., Fri, 07/06/2007
CAG counts are not related to the probability of developing a psychiatric disorder nor the severity of psychiatric symptoms in HD gene carriers.
CAG Counts: Intermediate alleles
Marsha Miller Ph.D., Sat, 09/16/2006
It has been awhile since a review of CAG counts in Huntington's Disease was published, so the new article by Dr. Michael Hayden and colleagues is very helpful. The normal, intermediate, and reduced penetrance ranges have changed over time and there have also been errors in publications. The authors present the most current information in the table below.
CAG Counts: Intermediate alleles
Marsha L. Miller, Ph.D., Fri, 09/15/2006
It has been awhile since a review of CAG counts in Huntington's Disease was published, so the new article by Dr. Michael Hayden and colleagues is very helpful. Here's a review of the latest informatio
NR2A and NR2B Receptor Gene Variations Modify Age at Onset in HD
Arning L, Kraus PH, Valentin S, Saft C, Andrich J, Epplen JT., Sun, 03/13/2005
Additional evidence for the role of excitotoxicity in HD pathology is provided by this study.
Other genes found to influence age of onset in HD
Chattopadhyay B, Baksi K, Mukhopadhyay S, Bhattacharyya NP, Fri, 01/14/2005
Variations in the TP53 and hCAD genes influence the age of onset for HD.
