A team of researchers from Barcelona, Spain, led by Dr. Mark Isalan and Dr. Mireia Garraga-Canut, have developed artificial zinc finger protein strands which bind the longer CAG repeat stretches of the HD protein while leaving the normal huntingtin protein gene, neighboring genes, and other genes with CAG repeat stretches unaffected. They achieved a 60 percent reduction of the HD protein in a mouse model and improved symptoms.
This is wonderful news. RNAi is probably going to be our virtual cure.
Overexpression of the RCAN1 gene may be a treatment for Huntington's Disease.