About Creatine

Creatine for Brain as well as Body

This section is devoted to what we currently know about creatine and what role creatine may play in the battle against Huntington's Disease. You probably know of creatine as a supplement for muscle builders. But creatine has also been shown to have some interesting properties that have HD researchers excited. Read on for more details.

Creatine is a compound which has been found to slow disease progression and increase survival time in the R6/2 mouse model of HD. It has been found to be safe and well tolerated in Huntington's patients and is currently in clinical trials. Creatine addresses two sources of pathology in Huntington's Disease. Mitochondrial dysfunction results in energy impairment; creatine boosts cellular energy. In addition, oxidative stress occurs with aging and neurodegenerative disorders including Huntington's; creatine is an antioxidant.